QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
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Location:
Lahore, Pakistan
haw main nay kab jagaya woh pehlay Twnikle twinkle little star wala sms kiss nay kya tha main nay to sehri k waqt(pakistani) oss ka sirf reply kya tha tumbhi meri tarha raat ko warning tones Viberation main badal diya karo na
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
I think SAWAB ki term logon k khud ki hi banaye gaye hai Jahan tak mera naqis Ilm hai Allah nay jis tarha Naiki aur badi ko differ kya hai issi tarha oon k results ko bhi define kya hai jis ko AJER ya SIlA kah saktay hain
ager koi is lalach main ibadat karay k sonay k mehal milain gay to ghalat hai haan ager woh Allah ki raza hasil karnay k liye kuch bhi naiki karay to woh oos ka Ajer ya sila ho ga
jahan tak sall tum nay rutbay ki baat ki hai to woh wahan melon say nahin AMAAL k lihaz say banay ga
jis tarha aik class main merit banta hai 1st 2nd aur third aur issi tarha oon k przes ka size bhi different hota hai may be insanon ki Naikiyun ki tadad per wahan bhi merit banay lakin yeh bhi pakka nahin BCZ kissi ki aik naiki oos k sab gunahon per bhari hai aur koi sari zindagi sajday main reh ker bhi kisi aik lamhay ki qaid main aa sakta hai
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
Johnson foresees a time when family members with a genetic predisposition to Alzheimer's disease could take a yet-undeveloped drug to increase transthyretin protein and prevent the disease from developing. Theoretically, the drug also could be given in the early stages of Alzheimer's to stop progression of the disease, preserving a higher level of cognitive function in patients.
The transthyretin discovery will likely impact the screening of environmental chemicals for their potential role in causing or exacerbating Alzheimer's disease. "Researchers could develop tests that determine whether a particular chemical or agent in the environment is able to shift the delicate balance between the 'good' and 'bad' proteins," notes Johnson. "This would allow scientists to establish definitive links between environmental exposures and Alzheimer's disease pathology."
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
Test tube studies with cultured brain cells from human cortex support the findings. When Stein treated human brain cells with the transthyretin protein, then exposed the cells to the toxic beta-amyloid, the brain cell de ath was minimal. "Now that we have demonstrated that this protective mechanism is relevant to humans, we can start to identify strategies to slow nerve degeneration in Alzheimer's patients," says Johnson.
According to Johnson, this would involve developing drugs that would boost the transthyretin within the brain or methods depositing transthyretin into the brain. "Hopefully this research will inspire a new approach to the treatment of Alzheimer's, one focused on preventing the loss of the brain cells instead of treating the resulting symptoms."
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
Johnson discovered the effect of transthyretin while studying mice genetically engineered with defective genes taken from human patients with early-onset Alzheimer's disease. As expected, the defective genes produced mice with higher-than-normal levels of the toxic beta-amyloid protein. These mice did not, however, exhibit symptoms of Alzheimer's disease.
"We have a mouse whose brain is bathing in toxic beta-amyloid without exhibiting disease symptoms," says Johnson. "We were all asking the same question -- Why aren't these nerve cells dying?"
Dr. Thor Stein, a researcher in Johnson's laboratory and first author of the study, then analyzed the brains of mice and noticed that the levels of transthyretin had increased dramatically. When Stein treated the mouse brain with an antibody that prevented transthyretin from reacting with the beta-amyloid protein, the mice showed brain cell de ath. "We concluded that the transthyretin must have protected the brain cells from the toxic effects of the beta-amyloid," says Johnson.
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
"The results of this study are promising," said Kenneth Olden, Ph.D., director of the NIEHS. "More studies are needed to understand how transthyretin can be used in treating Alzheimer's patients."
Alzheimer's disease progresses when a toxic protein, known as "beta-amyloid," attacks the brain's nerve cells involved in learning and memory. The beta-amyloid creates sticky plaques and tangles that gradually disable nerve cells, producing memory loss. Transthyretin appears to protect brain cells by intercepting the beta-amyloid and preventing it from interacting with the brain tissue.
"Based on the results of animal studies, we know that the disease process depends in large part on the delicate balance between the 'good' transthyretin protein and the 'bad' beta-amyloid protein," says Dr. Jeff Johnson, associate professor at the University of Wisconsin's School of Pharmacy and lead author on the study. "In Alzheimer's patients, the 'bad' proteins significantly outnumber the 'good' proteins."
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
ALZHEIMER's DISEASE Researchers have identified a protein in the brain that halts the progression of Alzheimer's disease in human brain tissue. The protein, known as "transthyretin," protects brain cells from gradual deterioration by blocking another toxic protein that contributes to the disease process.
The National Institute of Environmental Health Sciences, a component of the National Institutes of Health, provided $1.25 million to University of Wisconsin-Madison scientists for the transthyretin study. The scientists will present their findings October 26 at the 34th annual meeting of the Society for Neuroscience in San Diego, Calif.
QUEEN VICTORIA
Age: 124
7837 days old here
Total Posts: 26285
Points: 0
Location:
Lahore, Pakistan
thanx all D guls for support
SOffi no SMS weedo g ko mota karogi kya aftariyan khila khila k
SAHAILI dear aaj kal kuch busy hoon ,kuch net masti karta hai aur kuch try karti hoon k jo time milay woh yahan spend na kar k Ramazan ka haq ada kar sakoon (sirf koshish karti hoon warna bohat gunhagaar hoon) Inshallah after Eid I will be regular Take care all of u
kab, kahan , kisko offer ki thi tum nay
